OC 5107 CHEMICAL SYNTHESIS I
The first part of the course will introduce the major classes of synthetic transformations with a heavy emphasis on methods and reaction mechanisms. Control of reaction regio- and chemoselectivity in the assembly of carbon-carbon, carbon-heteroatom, and heteroatom-heteroatom bonds will be discussed.
Multiple tactics for acyclic diastereoselection will be covered during discussions of the Aldol and Claisen condensations. Olefin synthesis, principles of transition-metal catalysis, and the major types of carbon-based cycloadditions will conclude the first eight-week session.