This course will introduce the methodology and thinking required for approaching biomedical and basic science informatics research problems. Students will learn to independently clean, organize, analyze, explore, visualize, and model data using the programming language R. Additionally, this course should prepare students to have the confidence and capability to break down, understand, and interrogate scientific code and analytical workflows found in literature. Beginning with the basics of R programming, the course will develop foundational knowledge in statistics, numerical analysis, and data modeling, including elements of machine learning.